Actividad antiulcerosa en extracto crudo de Paeonia mascula subsp. atlantica (Coss.) Greuter & Burdet

• Wafa Nouioua Ferhat Abbas University Setif 1, Faculty of Natural and Life Sciences, Department of Plant Ecology and Biology, Laboratory of phytotherapy applied to chronic diseases. Setif, Algeria
• Sofiane Gaamoune National Institute of Agriculture Research. Setif, Algeria

DOI: https://doi.org/10.52973/rcfcv-e34423

Palabras clave: Antiulceroso, extracto crudo, Paeonia mascula, preventivo, curativo

Resumen

La afección por úlcera péptica representa un riesgo sanitario crítico, que provoca un sufrimiento y una mortalidad considerables. Surge de un desequilibrio entre las variables de fuerza que dañan el revestimiento mucoso del estómago y los componentes protectores que lo aseguran. Las curas convencionales a base de plantas han cobrado fuerza como opciones potenciales a los fármacos ordinarios. Este experimento pretendía evaluar la acción antiulcerosa del extracto crudo de Paeonia mascula con dos pruebas in vivo utilizando ratas Wistar macho. La prueba preventiva consistió en inducir lesiones gástricas agudas, mientras que la prueba terapéutica consistió en tratar la lesión con extracto crudo y cuantificar in vitro parámetros estomacales como el volumen gástrico, el pH, la acidez total, la actividad de la pepsina y el índice de úlcera. Los resultados ilustraron una notable reducción del índice de úlcera en las pruebas preventivas y curativas. Estos descubrimientos recomiendan que el extracto tiene un impacto antiulcerogénico al sofocar la secreción corrosiva y disminuir las lesiones estomacales.

Citas

Zapata–Colindres JC, Zepeda–Gomez S, Montaño–Loza A, Vasquez–Ballesteros E, Villalobos J, Valdovinos–Andraca F. The association of Helicobacter pylori infection and nonsteroidal anti–inflammatory drugs in peptic ulcer disease. Can. J. Gastroenterol. [Internet]. 2006; 20(4):277–280. doi: https://doi.org/g7m9dr

Barazandeh F, Yazdanbod A, Pourfarzi F, Sepanlou SG, Derakhshan MH, Malekzadeh R. Epidemiology of peptic ulcer disease: endoscopic results of a system investigation in Iran. Middle East J. Dig. Dis. [Internet]. 2012 [cited 20 Apr. 2024]; 4(2):90–96. PMID: 24829640. Available in: https://goo.su/V9cOv

Calam J, Baron JH. Pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ [Internet]. 2001; 323(7319):980–982. doi: https://doi.org/cfrz7s

Klein–Júnior LC, Santin JR, Niero R, Andrade SF, Cechinel–Filho V. The therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer. Phytochem. Rev. [Internet]. 2012; 11(4): 567–616. doi: https://doi.org/g7m9ds

Cordeiro KW, Pinto LA, Formagio ASN, Andrade SF, Kassuya CAL, Freitas KC. Antiulcerogenic effect of Croton urucurana Baillon bark. J. Ethnopharm. [Internet]. 2012; 143(1):331–337. doi: https://doi.org/gq7gjz

Akomas SC, Ezeifeka GO, Ijioma SN. Justification for the use of Musa paradisiaca green fruit extract for GIT mucosa protection and ulcer treatment. Cont. J. Anim. Vet. Res. [Internet]. 2014; 6(1):29–35. doi: https://goo.su/QaczT

Motamed SM, Naghibi F. Antioxidant activity of some edible plants of the Turkmen Sahra region in northern Iran. Food Chem. [Internet] 2010; 119(4):1637–1642. doi: https://doi.org/bcz7fq

Mizui T, Doteuchi M. Effect of polyamines on acidified ethanol–induced gastric lesions in rats. Jpn. J. Pharm. [Internet] 1983; 33(5):939–945. doi: https://doi.org/g7m9dz

Süleyman H, Akçay F, Altinkaynak K. The effect of nimesulide on the indomethacin – and ethanol–induced gastric ulcer in rats. Pharm. Res. [Internet] 2002; 45(2):155–158. doi: https://doi.org/cdhqkm

Devendra K, Surendra P, Kartik CP. Antiulcer activity of ethanolic extract of Buchanania lanzan Spreg roots. Ann. Biol. Res. [Internet]. 2010 [cited 19 Feb. 2024]; 1(4):234–239. Available in: https://goo.su/s8WH

Jaikumar S, Ramaswamy S, Asokan BR, Mohan T, Gnanavel M. Anti–ulcer activity of methanolic extract of Jatropha curcas (Linn.) on Aspirin–induced gastric lesions in Wistar strain rats. Res. J. Pharm. Biol. Chem. Sci. [Internet]. 2010 [cited 24 Feb 2024]; 1(4):886–897. Available in: https://goo.su/IfvCt

Hawk PB. Hawk’s physiological chemistry. 14th ed. New York: McGraw–Hill, Blakiston Division; 1965. 1472 p.

Vinothapooshan G, Sundar K. Anti–ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. Res. J. Pharm. Biol. Chem. Sci. [Internet]. 2010 [cited 18 Feb. 2024]; 1(4):606–614. Available in: https://goo.su/dgUBU

Smeeta MM, Subhash LB. Anti–ulcer activity of petroleum ether extract of leaves of Madhuca indica J. F. Gmel against pylorus ligation and naproxen–induced gastric mucosal injury in rats. Der. Pharm. Lettre. [Internet]. 2013 [cited 12 Feb. 2024]; 5(2):205–211. Available in: https://goo.su/yDj9i

Arab HH, Salama SA, Eid AH, Kabel AM, Shahin NN. Targeting MAPKs, NF–κB, and PI3K/AKT pathways by methyl palmitate ameliorates ethanol–induced gastric mucosal injury in rats. J. Cell. Physiol. [Internet]. 2019; 234(12): 22424–22438. doi: https://doi.org/gjg7r2

Akanda MR, Park BY. Involvement of MAPK/NF–κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer. Biomed. Pharmacother. [Internet]. 2017; 95:1139–1146. doi: https://doi.org/gcqq9c

Kwiecien S, Jasnos K, Magierowski M, Sliwowski Z, Pajdo R, Brzozowski B, Mach T, Wojcik D, Brzozowski T. Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress–induced gastric injury. J. Physiol. Pharm. [Internet]. 2014 2013 [cited 12 Feb. 2024]; 65(5)613–622. PMID: 25371520. Available in: https://goo.su/fIjpitj

Chen S, Zhao X, Sun P, Qian J, Shi Y, Wang R. Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice. J. Pharm. Sci. [Internet]. 2017; 133(1):1–8. doi: https://doi.org/f9v32b

Zhang W, Lian Y, Li Q, Sun L, Chen R, Lai X, Lai Z, Yuan E, Sun S. Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules [Internet]. 2020; 25(20):4626. doi: https://doi.org/gsch43

Ashoka MS, Shashidhar CS, Prakash S. Anti Ulcer Activity of Heliotrpium Indicum Leaves Extract. Int. J. Pharm. Sci. Res. [Internet]. 2011; 2(5):1288–1292. doi: https://doi.org/g7m9d4

Robert A. Cytoprotection by prostaglandins. Gastroenterology [Internet]. 1979; 77(4):761–767. doi: https://doi.org/g7m9d5

Konda Y, Sakamoto C, Nishisaki H, Nakano O, Matozaki T, Nagao M, Matsuda K, Wada K, Baba S. Ethanol stimulates pepsinogen by opening a Ca2+ channels of guinea pig gastric chief cells. Gastroenterology [Internet]. 1991; 100(1):17–24. doi: https://doi.org/g7m9d7

Karmeli F, Eliakim R, Okon E, Rachmilewitz D. Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer. Gastroenterology [Internet]. 1991; 100(5 Pt 1):1206–1216. doi: https://doi.org/g7m9d8

Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology [Internet]. 1985; 88(1 Pt 2):228–236. doi: https://doi.org/gp3wp2

Kauffman Jr. GL. Can the mechanisms of aspirin induced gastric mucosal injury be identified? [Internet]. In: Yoshida H, Hagihara Y, Ebashi S, editors. Toxicology & Experimental Models. Proceedings of the 8th International Congress of Pharmacology; 1981; Tokyo. New York: Pergamon Press; 1981. p. 281–285. doi: https://doi.org/nnck

Horowitz MI, Pigman W. The Glycoconjugates. Vol. 1, Mammalian Glycoproteins and Glycolipids. New York: Academic Press; 1977. Chapter 3, Section 5, Gastrointestinal glycoproteins; p. 189–213.