El extracto de Ginkgo biloba L. y la flunixina meglumina atenúan la lesión hepática, el estrés oxidativo, la inflamación y la apoptosis asociados a la sepsis en ratas

• Tuba Parlak Ak University of Munzur, Faculty of Health Sciences, Department of Nutrition and Dietetics.Tunceli, Türkiye
• Burcu Gul University of Firat, Faculty of Health Sciences, Department of Nursing. Elazig, Türkiye
• Mine Yaman University of Firat, Faculty of Veterinary Medicine, Department of Histology and Embryology. Elazig, Türkiye
• Ismail Seven University of Firat, Vocational School of Sivrice, Department of Plant and Animal Production. Elazig, Türkiye
• Gurdal Dagoglu University of Firat, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology. Elazig, Türkiye
• Huseyin Fatih Gul University of Kafkas, Faculty of Medicine, Department of Biochemistry. Kars, Türkiye

DOI: https://doi.org/10.52973/rcfcv-e34501

Palabras clave: Flunixina meglumina, extracto de Ginkgo biloba L., daño hepático, septicemia

Resumen

El lipopolisacárido (LPS), conocido como un estimulante de la inflamación, causa daño hepático agudo al inducir la producción de mediadores inflamatorios y estrés oxidativo. El propósito de este estudio es determinar si un fármaco antiinflamatorio no esteroide (AINE) Flunixin meglumine (FM) y un agente natural extracto de Ginkgo biloba L. (GBE) muestran efectos antioxidantes, antiinflamatorios o antiapoptóticos en el tejido hepático en la hepatotoxicidad inducida por LPS. Los animales se separaron en 6 grupos como control, sepsis (1 mg·kg^-1, dosis única el séptimo día, intraperitoneal (ip)), sepsis + FM (1 mg·kg^-1, dosis única el séptimo día, ip + 2,2 mg·kg^-1 día, ip), sepsis + GBE (1 mg·kg^-1, dosis única el séptimo día, ip + 50 mg·kg^-1 día, sonda), FM y GBE y el estudio continuó durante 7 días. Los tejidos hepáticos extraídos de ratas sacrificadas se analizaron bioquímicamente, histológicamente e inmunohistoquímicamente. En consecuencia, el LPS provocó alteración de los marcadores de la función hepática, inflamación, estrés oxidativo y apoptosis, así como cambios histopatológicos en el tejido hepático. Sin embargo, se observó que los cambios inducidos por LPS fueron regulados por la aplicación de FM y GBE. Se demostró que FM y GBE tienen propiedades antioxidantes, antiinflamatorias y antiapoptóticas en la hepatotoxicidad inducida por LPS.

Citas

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