Características clínicas, macroscópicas, citomorfológicas e histopatológicas del tumor venéreo transmisible canino en dos perras: Primer informe de Kirguistán. Caso clinico.
Resumen
El tumor venéreo transmisible canino (TVTC) es un cáncer transmisible de origen natural que se propaga entre perros mediante la transferencia alogénica de células cancerosas vivas. La enfermedad suele transmitirse durante el coito y da lugar a la aparición de tumores asociados con mayor frecuencia a los genitales externos de perros machos y hembras. En este informe de caso, se pretende describir los hallazgos clínicos, citológicos, macroscópicos e histopatológicos de dos perras con CTVT. En el examen clínico de ambas perras, una cruza de Husky de 8 meses y una Alabai de 2 años, se observaron estructuras protuberantes, irregulares, ulceradas y sangrantes en la vulva. En los exámenes citológicos, se observaron células de forma redonda a poliédrica con un núcleo situado excéntricamente, mitosis múltiples y las características vacuolaciones citoplasmáticas con contornos claros. Los exámenes histopatológicos de ambos casos revelaron células neoplásicas redondas o poliédricas dispuestas en sábanas o hileras sólidas sostenidas por septos de tejido conectivo fibrovascular. También se observaron numerosas figuras mitóticas junto con las células tumorales. Las células tumorales con bordes celulares indistintos presentaban estructuras citoplasmáticas eosinofílicas y finamente granulares. También se observaron cambios necróticos en las células tumorales y focos de hemorragia. En la luz del vaso se observó una embolia de células tumorales adheridas a la pared del vaso. Se cree que estos casos son importantes porque se notifican por primera vez en Kirguistán.
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Cohen D. The biological behaviour of the transmissible venereal tumour in immunosuppressed dogs. Europ. J. Can. [Internet]. 1973; 9(4):253-258. doi: https://doi.org/dw5vcd DOI: https://doi.org/10.1016/0014-2964(73)90090-X
Setthawongsin C, Techangamsuwan S, Rungsipipat A. Canine transmissible venereal tumor: An infectious neoplasia in dogs. In: Fonseca-Alven CE, editor. Recent Advances in Canine Medicine. London, UK: IntechOpen. [Internet]. 2023; pp. 1–15. doi: https://doi.org/pprc DOI: https://doi.org/10.5772/intechopen.106150
Yang TJ, Jones JB. Canine transmissible venereal sarcoma: Transplantation studies in neonatal and adult dogs. J. Nat. Can. Inst. [Internet]. 1973; 51(6):1915-1918. doi: https://doi.org/pprd DOI: https://doi.org/10.1093/jnci/51.6.1915
Hiblu MA, Khabuli NM, Gaja AO. Canine transmissible venereal tumor: First report of three clinical cases from Tripoli, Libya. Open Vet. J. [Internet]. 2019; 9(2):103-105. doi: https://doi.org/pprf DOI: https://doi.org/10.4314/ovj.v9i2.1
Kabuusu RM, Stroup DF, Fernandez C. Risk factors and characteristics of canine transmissible venereal tumours in Grenada, West Indies. Vet. Comp. Oncol. [Internet]. 2010; 8(1):50–55. doi: https://doi.org/b524bg DOI: https://doi.org/10.1111/j.1476-5829.2009.00204.x
Ostrander EA, Davis BW, Ostrander GK. Transmissible tumors: breaking the cancer paradigm. Trends Genet. [Internet]. 2016; 32(1):1–15. doi: https://doi.org/f762ft DOI: https://doi.org/10.1016/j.tig.2015.10.001
Das U, Das AK. Review of canine transmissible venereal sarcoma. Vet. Res. Commun. [Internet]. 2000; 24:545-556. https://doi.org/bzj2x2
Strakova A, Murchison EP. The changing global distribution and prevalence of canine transmissible venereal tumour. BMC Vet. Res. [Internet]. 2014; 10:168. doi: https://doi.org/f6fp4q DOI: https://doi.org/10.1186/s12917-014-0168-9
Ishaq I, Jamil H, Farooq M, Ullah Q, Khan MZ, Mushtaq R, Lodhi FL, Maqbool B, Hussain S, Muner RD, Ziaullah Lodhi LA. Comparative evaluation of vincristine sulfate and vinblastine sulfate for the treatment of transmissible venereal tumor in dogs: a pre-clinical and pathological study. Pak. J. Zool. [Internet]. 2025; 2025:1-7. doi: https://doi.org/pprg DOI: https://doi.org/10.17582/journal.pjz/20230606060602
Park M, Kim Y, Kang M, Oh S, Cho D, Shin N, Kim D. Disseminated transmissible venereal tumor in a dog. J. Vet. Diagn. Investig. [Internet]. 2006; 18(1):130-133. doi: https://doi.org/djcv93 DOI: https://doi.org/10.1177/104063870601800123
Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JM, Werner EI, Allen J, De Nardi, AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR. Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science [Internet]. 2014; 343(6169):437–440. doi: https://doi.org/q7r DOI: https://doi.org/10.1126/science.1247167
Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell [Internet]. 2006; 126(3):477–487. doi: https://doi.org/cxnvrf DOI: https://doi.org/10.1016/j.cell.2006.05.051
Thangathurai R, Amirthalingam Balasubramaniam G, Dharmaceelan S, Balachandran P, Srinivasan P, Sivaseelan S, Murali Manohar B. Cytological diagnosis and its histological correlation in canine transmissible venereal tumour. Vet. Arhiv [Internet]. 2008 [cited Jan 12 2025]; 78(5):369-376. Available in: https://goo.su/pWHrxPJ
Kumar VVVA, Kumari KN, Kumar KS, Kumar VG, Lakshman M. Hemato-biochemical changes in transmissible venereal tumors (TVT) affected dogs. Pharm. Innov. J. [Internet]. 2017 [cited Jan 12 2025]; 6(12):313-315. Available in: https://goo.su/lNZqv
Ganguly B, Das U, Das A. Canine transmissible venereal tumour: a review. Vet. Comp. Oncol. [Internet]. 2016; 14(1):1-12. doi: https://doi.org/pprh DOI: https://doi.org/10.1111/vco.12060
Oruc E, Hatipoglu F, Ortatatli M, Ates MB, Terzi F, Celebi A, Ozdemir O, Ciftci MK. A Case of Unusual Settled Transmissible Venereal Tumor in the Nasal Cavity of a Male Dog. En: International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018). Ankara,Türkiye: Abstract book; 26 - 27 April 2018. p. 127. Available in: https://goo.su/PtTqUE
Ozdemir O, Ortatatlı M, Hatipoglu F, Ciftci MK, Ates MB. Terzi F. Transmissible Venereal Tumor (TVT) with Metastasized Lymph Node And Scrotum in A Pitbull Dog. In: VIII. National Veterinary Pathology Congress. 1-3 September 2016, Samsun,Türkiye: Abstract; 2016. p. 81-82. Available in: https://goo.su/3bQot
Souto EPF, Rissi DR, Oliveira AM, Garcia DS, Mota RA, de Souza AP, Galiza GJN, Dantas AFM. Transmissible venereal tumour with encephalic metastasis in dogs. J. Comp. Pathol. [Internet]. 2025; 216:25-32. doi: https://doi.org/pprk DOI: https://doi.org/10.1016/j.jcpa.2024.11.004
Luna LG. Manual of histologic staining methods of the armed forces ınstitute of pathology. 3rd ed. New York: McGraw-Hill; 1968.
Aja TN, Becha BB, Jayakumar C, Unnikrishnan MP, Devi SS. Occurrence of canine transmissible venereal tumour. J. Vet. Anim. Sci. [Internet]. 2023; 54(2):382-387. doi: https://doi.org/pprm DOI: https://doi.org/10.51966/jvas.2023.54.2.382-387
Cohen D. The canine transmissible venereal tumor: a unique result of tumor progression. Adv. Cancer Res. [Internet]. 1985; 43:75–112. doi: https://doi.org/dr42n9 DOI: https://doi.org/10.1016/S0065-230X(08)60943-4
Pimentel PAB, Giuliano A, Odatzoglou P, Ignatenko N, Wenceslau RR, Almeida IO, da Silva PHS, Costa MP, Horta RDS. Clinical guidelines for canine transmissible venereal tumour treatment: systematic review and meta-analysis. Vet. Comp. Oncol. [Internet]. 2025; 23(2):125-140. doi: https://doi.org/pprn DOI: https://doi.org/10.1111/vco.13038
Laissaoui N, Millán Y, Betz DS, Mrini ME, Bouayad G, Lamalmi N, Tligui N, Azrib R. Canine transmissible venereal tumor in Morocco: Clinical and pathological findings in 64 dogs-insights from a descriptive epidemiological study (2020-2023). Open Vet. J. [Internet]. 2024; 14(5):1206-1215. doi: https://doi.org/pprp DOI: https://doi.org/10.5455/OVJ.2024.v14.i5.16
Florez MM, Pedraza F, Grandi F, Rocha NS. Cytologic subtypes of canine transmissible venereal tumor. Vet. Clin. Pathol. [Internet]. 2012; 41(1):4-5. doi: https://doi.org/pprr DOI: https://doi.org/10.1111/j.1939-165X.2012.00401.x
Henson KL. Reproductive system. In: Atlas of canine and feline cytology. W.B. Philadelphia, PA, USA: Saunders Co, 2001, p. 296–297.
Hendrick MJ. Mesenchymal tumors of the skin and soft tissues. In: Meuten DJ, editor. Tumors in domestic animals, 5th ed. Ames, USA: John Wiley & Sons Ltd., Inc. 2017. p.158-160.
Foster RA. Male reproductive system. In: Zachary JF editör. Pathologic basis of veterinary disease, Sixth ed. Mosby, USA: Elsevier. 2017, p. 1194-1222. DOI: https://doi.org/10.1016/B978-0-323-35775-3.00019-9
Correa FL, Wolfran L, Viott AM, Goulart JC, Jojima FS, Agostini P. Pulmonary metastasis of transmissible venereal tumour in a dog: a casereport. Acta. Vet. Bras. [Internet]. 2021; 15(3):192–197. doi: https://doi.org/pprs DOI: https://doi.org/10.21708/avb.2021.15.3.9809
Hayes AM, Schiavo L, Constantino-Casas F, Desmas I, Dobson J, Draper A, Elliot J, Genain MA, Wang J, Murchison EP. Transmission of canine transmissible venereal tumour between two dogs in the UK. J. Small. Anim. Pract. [Internet]. 2023; 64(9):590-594. doi: https://doi.org/pprt DOI: https://doi.org/10.1111/jsap.13607
Saat N, Çetinkaya YB. An overview diagnosis and treatment methods in cases of transmissible venereal tumor in female dogs. Manas J. Agric. Vet. Life Sci. [Internet]. 2024;14(2):268-272. doi: https://doi.org/pprv DOI: https://doi.org/10.53518/mjavl.1520849
