Jaundice hepatocellular origin, what to do?

Ictericia de origen hepatocelular ¿Qué hacer?

• Maribel Lizarzábal-García Universidad de Zulia http://orcid.org/0000-0002-6185-5163

DOI: https://doi.org/10.5281/zenodo.5680052

Keywords: jaundice hepatocellular, autoimmune hepatitis, Wilson ́s disease, hemochromatosis, α1-antitrypsin deficiency

Abstract

Jaundice of hepatocellular origin is characterized by elevated serum bilirubin and
transaminases alanine amino transferase and aspartate amino transferase. A series of causative diseases such as autoimmune hepatitis, Wilson's disease, hemochromatosis, α1-antitrypsin deficiency, viral hepatitis, hepatotoxicity, alcoholic and non-alcoholic fatty liver disease must be ruled out. The diagnosis of autoimmune hepatitis is based on histological abnormalities (interface hepatitis), characteristic clinical and laboratory findings. The key features of Wilson's disease are liver disease, neuropsychiatric abnormalities, Kayser-Fleischer rings in the Desçemet's membrane of the cornea, and acute episodes of hemolysis often associated with acute liver failure. Evaluation of patients with suspected hemochromatosis includes measurement of serum iron, ferritin, and transferrin-iron saturation. Finally, α1-antitrypsin deficiency is the hereditary disorder associated with developing pulmonary emphysema and liver disease, and quantitative determination of α1-antitrypsin levels in the blood is crucial for its identification.

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