Cuando sospechar Enfermedad Celíaca y que órganos afecta
When to suspect celiac disease and what organs does it affect?
Palabras clave:
enfermedad celiaca, dieta libre de gluten, diabetes mellitus, tiroiditis, hepatitis autoinmune, anemia
Resumen
La enfermedad celiaca (EC) es una condición autoinmune con base genética, ya que se desarrolla en personas susceptible en respuesta a la exposición del gluten. La prevalencia mundial se estima de 1 persona por cada 100, que puede variar según la zona geográfica. Se presenta con manifestaciones intestinales y extraintestinales, que no son específicas y requiere un alto grado de sospecha. Además, puede estar asociada a otras enfermedades autoinmune. Los síntomas clásicos se deben a la malabsorción intestinal, con buena respuesta a la dieta libre de gluten. El espectro clínico extradigestivo es muy amplio con afección hematológica, neurológica, dermatológica, oral, dentaria, hepática entre otras. Se debe conocer que Diabetes mellitus tipo 1 y Tiroiditis autoinmune son patologías asociadas, donde el diagnóstico es crucial.
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Citas
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Van Kalleveen M, de Meij T, Plöötz F. Clinical spectrum of paediatric coeliac disease: a 10-year single-centre experience. Eur JPediatr 2018;177:593–602.
Popp A, Makki M. Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease - Celiac Trait. Nutrients 2019 ;11 :320-326.
Reilly N, Aguilar K, Hassid B, Cheng J, Defelice A, Kazlow P, y col. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528–531.
Therrien A, Ciaram K, Silvester J. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol 2020; 54 (1): 8-21.
Caio G, Volta U, Sapone A, Leffler D, De Giorgio R, Catassi C, Fasano A. Celiac disease: a comprehensive current review. BMC Med 2019;17(1):142.
Panezai M, Ullah A, Ballur K, Gilstrap L, Khan J, y col. Frequency of Celiac Disease in Patients With Chronic Diarrhea. Cureus 2021;13(12):e20495.
Horton R, Hagen C, Snyder M. Pediatric Celiac Disease: A Review of Diagnostic Testing and Guideline Recommendations. The Journal of Applied Laboratory Medicine 2022; 7(1):294–304.
Ludvigsson J, Leffler D, Bai J, Biagi F, Fasano A, Green H, y col. The Oslo definitions for coeliac disease and related terms. Gut 2013; 62: 43-52.
Durazzo, M, Ferro A, Brascugli I, Mattivi S, Fagoonee S, y col. Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? J Clin Med 2022;11:258..
Rispo A, Imperatore N, Guarino M, Tortora R, Alisi A, Cossiga V, Testa A, Ricciolino S, y col. Metabolic-associated fatty liver disease (MAFLD) in coeliac diseaseLiver International 2021;41(4):788-798.
Nardecchia S, Auricchio R, Discepolo V and Troncone R. Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms. Front Pediatr 2019; 7:56.
Balaban D, Popp A, Ionita Radu F, Jinga M. Hematologic Manifestations in Celiac Disease A Practical Review. Medicina 2019;55:373-376.
Laurikka P, Nurminen S, Kivelä L, Kurppa K. Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes. Nutrients 2018;10(8):1015.
Rodrigo L, Betetai V, Alvarez N, Gómez , de Dios A, Palacios L, Santos J. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. Nutrients 2018;10(7):800.
Coronel C, Rodríguez A. Neurological Manifestations of the Celiac Disease in Children. OBM Neurobiology 2020; 4(3): 066.
Giuffrè M, Gazzin S, Zoratti C, Llido J, Lanza G, y col. Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation. Int J Mol Sci 2022;23:15564.
Kumar K, Rustogi D. Extraintestinal Manifestations of Celiac Disease in Children. IntechOpen. 2023.
Flores G, Islam H, Puttagunta S, Islam R, Kundu S, Jha S, Rivera A, Sange I. Association Between Type 1 Diabetes Mellitus and Celiac Disease: Autoimmune Disorders With a Shared Genetic Background. Cureus 2022;14(3):e22912.
Ashok T, Patni N, Fatima M, Lamis A, Siddiqui S. Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod. Cureus 2022;14(6):e26243.
Bai J, Ciacci C, Corazza G, Schuppan D, Farthing M, y col. Celiac Disease 2016 World Gastroenterology Organisation Guidelines. J Clin Gastroenterol 2013;47(2):121-126.
Méndez D, Arriola M, Gonzáles A, Montenegro C, Olano C. Prevalencia y características de la deficiencia selectiva de IgA en pacientes celíacos. Rev Gastroenterol Peru. 2021;41(1):11-15
Soltani Z, Baghdad A, Nejadhosseinian M, Faezi S, Shahbazkhani B, y col. Celiac disease in patients with systemic lupus erythematosus. Reumatologia 2021; 59(2): 85–89.
Singh P, Arora A, Strand T, Leffler D, Catassi C, y col. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018;16:823–836.e2.
Gujral N, Freeman H, Thomson A. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol 2012; 18(42): 6036-6059.
Volta U, Caio G, Stanghellini V, De Giorgio R. The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center. BMC Gastroenterol 2014;14:194.
Sahin Y. Celiac disease in children: A review of the literature. World J Clin Pediatr 2021; 10(4): 53-71.
Van Kalleveen M, de Meij T, Plöötz F. Clinical spectrum of paediatric coeliac disease: a 10-year single-centre experience. Eur JPediatr 2018;177:593–602.
Popp A, Makki M. Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease - Celiac Trait. Nutrients 2019 ;11 :320-326.
Reilly N, Aguilar K, Hassid B, Cheng J, Defelice A, Kazlow P, y col. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528–531.
Therrien A, Ciaram K, Silvester J. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol 2020; 54 (1): 8-21.
Caio G, Volta U, Sapone A, Leffler D, De Giorgio R, Catassi C, Fasano A. Celiac disease: a comprehensive current review. BMC Med 2019;17(1):142.
Panezai M, Ullah A, Ballur K, Gilstrap L, Khan J, y col. Frequency of Celiac Disease in Patients With Chronic Diarrhea. Cureus 2021;13(12):e20495.
Horton R, Hagen C, Snyder M. Pediatric Celiac Disease: A Review of Diagnostic Testing and Guideline Recommendations. The Journal of Applied Laboratory Medicine 2022; 7(1):294–304.
Ludvigsson J, Leffler D, Bai J, Biagi F, Fasano A, Green H, y col. The Oslo definitions for coeliac disease and related terms. Gut 2013; 62: 43-52.
Durazzo, M, Ferro A, Brascugli I, Mattivi S, Fagoonee S, y col. Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? J Clin Med 2022;11:258..
Rispo A, Imperatore N, Guarino M, Tortora R, Alisi A, Cossiga V, Testa A, Ricciolino S, y col. Metabolic-associated fatty liver disease (MAFLD) in coeliac diseaseLiver International 2021;41(4):788-798.
Nardecchia S, Auricchio R, Discepolo V and Troncone R. Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms. Front Pediatr 2019; 7:56.
Balaban D, Popp A, Ionita Radu F, Jinga M. Hematologic Manifestations in Celiac Disease A Practical Review. Medicina 2019;55:373-376.
Laurikka P, Nurminen S, Kivelä L, Kurppa K. Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes. Nutrients 2018;10(8):1015.
Rodrigo L, Betetai V, Alvarez N, Gómez , de Dios A, Palacios L, Santos J. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. Nutrients 2018;10(7):800.
Coronel C, Rodríguez A. Neurological Manifestations of the Celiac Disease in Children. OBM Neurobiology 2020; 4(3): 066.
Giuffrè M, Gazzin S, Zoratti C, Llido J, Lanza G, y col. Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation. Int J Mol Sci 2022;23:15564.
Kumar K, Rustogi D. Extraintestinal Manifestations of Celiac Disease in Children. IntechOpen. 2023.
Flores G, Islam H, Puttagunta S, Islam R, Kundu S, Jha S, Rivera A, Sange I. Association Between Type 1 Diabetes Mellitus and Celiac Disease: Autoimmune Disorders With a Shared Genetic Background. Cureus 2022;14(3):e22912.
Ashok T, Patni N, Fatima M, Lamis A, Siddiqui S. Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod. Cureus 2022;14(6):e26243.
Bai J, Ciacci C, Corazza G, Schuppan D, Farthing M, y col. Celiac Disease 2016 World Gastroenterology Organisation Guidelines. J Clin Gastroenterol 2013;47(2):121-126.
Méndez D, Arriola M, Gonzáles A, Montenegro C, Olano C. Prevalencia y características de la deficiencia selectiva de IgA en pacientes celíacos. Rev Gastroenterol Peru. 2021;41(1):11-15
Soltani Z, Baghdad A, Nejadhosseinian M, Faezi S, Shahbazkhani B, y col. Celiac disease in patients with systemic lupus erythematosus. Reumatologia 2021; 59(2): 85–89.
Publicado
2023-11-21
Cómo citar
Navarro, D. (2023). Cuando sospechar Enfermedad Celíaca y que órganos afecta: When to suspect celiac disease and what organs does it affect?. Revista Profesional HígadoSano, (26), 22-33. https://doi.org/10.5281/zenodo.10193957
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