Liver disorders in COVID - 19
Alteraciones hepáticas en COVID - 19
Keywords:
SARS-COV-2, COVID-19, liver disorders
Abstract
During the clinical course of COVID-19, alterations in liver function tests have been observed, particularly in those with severe or critical illness. In this review we will summarize the pathophysiology of SARS-CoV-2-induced liver injury. Approximately 60% of patients have been observed to develop varying degrees of liver injury. Alterations in liver function tests in COVID-19 patients manifest as abnormal ALT or AST levels, with a slight increase in bilirubin levels. Liver involvement in COVID-19 could be related to the direct cytopathic effect of the SARS-CoV-2 virus, an uncontrolled immune reaction, sepsis, or drug-induced liver injury.
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References
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Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, y cols. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513.
Chaibi S, Boussier J, Hajj W, Abitbol Y, Taieb S, Horaist C, y cols. Liver function test abnormalities are associated with a poorer prognosis in Covid-19 patients: Results of a French cohort. Clin Res Hepatol Gastroenterol. 2020:S2210-7401(20)30297-7.
Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5(5):428-430.
Cha M, Regueiro M, Sandhu D. Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review. World J Gastroenterol. 2020;26(19):2323-2332.
El Ouali S, Romero C, Regueiro M. Hepatic manifestations of COVID-19. Cleve Clin J Med. 2020. doi: 10.3949/ccjm.87a.ccc061.
Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M. COVID-19 and the liver. J Hepatol. 2020 Nov;73(5):1231-1240.
Li Y, Xiao SY. Hepatic involvement in COVID-19 patients: Pathology, pathogenesis, and clinical implications. J Med Virol 2020;92(9):1491-1494.
Published
2021-05-04
How to Cite
Lizarzábal-García, M., & Mengual-Moreno, E. (2021). Liver disorders in COVID - 19: Alteraciones hepáticas en COVID - 19. Revista Profesional HígadoSano, (20), 13-15. Retrieved from https://mail.produccioncientificaluz.org/index.php/higadosano/article/view/35797
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