VPH infection and its clinical correlation in indigenous population of the high andean region of Ecuador
Abstract
Cervical-uterine cancer (CaCu) is a public health problem. Epidemiological studies have identified a close relationship between CaCu and human papillomavirus (HPV) infection. The purpose of this study was to perform the molecular detection of HPV, identification of mixed infections and the screening of CaCu through conventional cytology in an indigenous population of the high Andean highlands of Ecuador in order to correlate the data obtained with the presence of lesions. Methodology: A cross-sectional study was carried out on 189 women between the ages of 21 and 65; who belonged to the community of Pilahuin in the province of Tungurahua, who assisted to gynecological check-ups. Data were analyzed with the EPI-INFO and SPSS statistical programs. Results: the average age of the participants was 35.2 years, most of the participants identified themselves as indigenous, in a stable relationship, multiparous, with a medium to low level of education and no paid work. The participants showed a favorable attitude towards the cervico-uterine cytology in 100% of the cases without showing a relation with age, level of education or civil status. HPV infection was positive in 10.5% of the participants, 70% of the patients had severe inflammation with a positive association with mixed bacterial infection.
References
Bosch F, Manos M, Munoz N, Sherman M, Jansen AM, Peto J, et al. Prevalence of Human Papillomavirus in Cervical Cancer: A Worldwide Perspective. Journal of the National Cancer Institute. 1995; 87(11):796-802.
Vaccarella S, Bray F. Epidemiology and Burden of Disease Associated with HPV Infection. Current Obstetrics and Gynecology Reports 2015; 4(4):181-8.
Roldós M, Bustamante V. Consensus of Clinical Practices and Associated Costs to Diagnose and Treat Genital Warts Caused By Human Papilloma Virus (HPV) In Ecuador: Results From A Panel Of Experts. Value in health: The Journal of the International Society for Pharmacoeconomics and Outcomes Research. 2015; 18(7): A833.
Moore S, Forman D, Piñeros M, Fernández S, Oliveira Santos M, Bray F. Cancer in indigenous people in Latin America and the Caribbean: a review. Cancer Medicine. 2014; 3(1):70-80.
Nwanodi O. Attitudes towards Human Papilloma Virus Vaccination in the Latin American Andean Region. Healthcare. 2017; 5(3):55.
Sykes P, Gopala K, Tan AL, Kenwright D, Petrich S, Molijn A, et al. Type distribution of human papillomavirus among adult women diagnosed with invasive cervical cancer (stage 1b or higher) in New Zealand. BMC infectious diseases. 2014; 14(1):374.
Paez C, Konno R, Yaegashi N, Matsunaga G, Araujo I, Corral F, et al. Prevalence of HPV DNA in Cervical Lesions in Patients from Ecuador and Japan. The Tohoku Journal of Experimental Medicine. 1996; 180(3):261-72.
Mejia L, Muñoz D, Trueba G, Tinoco L, Zapata S. Prevalence of human papillomavirus types in cervical cancerous and precancerous lesions of Ecuadorian women. Journal of Medical Virology. 2016; 88(1):144-52
Cecchini G, Paganini G, D'Amico M, Cannone M, Bertuletti C, Barberis MCP. Cervical cancer screening programs in low-income communities. Experiences from Ecuador. Low cost detection of HPV infection in a developing country. Pathologica. 2009; 101(2):76.
Cueva P, Yépez J; Eds. Epidemiología del cáncer en Quito 2006-2010. Registro Nacional de Tumores. 15 ed. Quito: Sociedad de Lucha Contra el Cáncer. SOLCA Núcleo de Quito; 2014.
Zhao J, Guo Z, Wang Q, Si T, Pei S, Wang C, et al. Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China. Infectious Agents and Cancer. 2017; 12(1).
de Sanjose S, Retrospective International S, Group HPVTTS. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. The lancet oncology. 2010; 11(11):1048-56.
García M, García R, Burgos G, Carpio FA. Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women. Revista Brasileira de Epidemiologia. 2016; 19(1):160-6.
Aguilar P, González C, Rodríguez A, Páez K, Arévalo A, Bobokova J. Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap smear Tests in Southern Ecuador. Infectious Diseases in Obstetrics and Gynecology. 2017; 2017.
Sotlar K, Diemer D, Dethleffs A, Hack Y, Stubner A, Vollmer N, et al. Detection and Typing of Human Papillomavirus by E6 Nested Multiplex PCR. Journal of Clinical Microbiology. 2004; 42(7):3176-84.
Magûes M, Guillermo L. Genotipificación del virus del papiloma humano mediante secuenciamiento y PCR cuantitativa en tiempo real y detección de variantes intratípicas por análisis fitogenético (B.S. thesis). 2015 Recuperado a partir de http://www.dspace.espol.edu.ec/xmlui/handle/123456789/29767
Mejia L, Muñoz D, Trueba G, Tinoco L, Zapata S. Prevalence of human papillomavirus types in cervical cancerous and precancerous lesions of Ecuadorian women. Journal of Medical Virology, 2016; 88(1), 144-152.
Aguilar P, González C, Córdoba Rodriguez A, Arevalo A, Bobokova J. Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador Infectious Diseases in Obstetrics and Gynecology 2017; 2017, Article ID 8572065. https://doi.org/10.1155/2017/8572065
Giuliano A, Nyitray A, Kreimer A, Pierce Campbell C, Goodman M, Sudenga S, et al. EUROGIN 2014 roadmap: Differences in human papillomavirus infection natural history, transmission and human papillomavirus‐related cancer incidence by gender and anatomic site of infection. International Journal of Cancer. 2015; 136(12):2752-60.
Camargo M, Soto-De Leon S, Sanchez R, Perez-Prados A, Patarroyo M, Patarroyo M. Frequency of Human Papillomavirus Infection, Coinfection, and Association with Different Risk Factors in Colombia. Annals of Epidemiology. 2011; 21(3):204-13.
Naranjo D, Naranjo S. Plan de desarrollo turístico comunitario para la parroquia Pilahuin, cantón Ambato provincia de Tungurahua. Tesis previa a la obtención del Título de Economista. Carrera de Economía. Quito: (2014) UCE. 259 p.
Ciapponi A, Bardach A, Glujovsky D, Gibbons L, Picconi M. Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: systematic review and meta-analysis. PloS one. 2011; 6(10): e25493.
Holme F, Slavkovsky R, Camel C. Implementation of HPV testing in Latin America. Journal of Clinical Virology. 2016; 76: S69-S73.
Copyright (c) 2019 Yenddy Carrero, Elizabeth Proaño-Pérez, Fernanda Vasquez, Alex Armijos, Carmen Viteri-Rpbayo, Alicia Zabala-Calahorrano
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Kasmera journal is registered under a Creative Commons an Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0), available at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en; which guarantees the freedom to share-copy and redistribute the material in any medium or format and adapt-remix, transform and build from the material, provided that the name of the authors, the Department of Infectious and Tropical Diseases, Zulia´s University and Kasmera Journal, you must also provide a link to the original document and indicate if changes have been made.
The Department of Infectious and Tropical Diseases, University of Zulia and Kasmera Journal do not retain the rights to published manuscript and the contents are the sole responsibility of the authors, who retain their moral, intellectual, privacy and publicity rights. The guarantee on the intervention of the manuscript (revision, correction of style, translation, layout) and its subsequent dissemination is granted through a license of use and not through a transfer of rights, which represents the Kasmera Journal and Department Infectious Diseases, University of Zulia are exempt from any liability that may arise from ethical misconduct by the authors.
Kasmera is considered a green SHERPA/RoMEO journal, that is, it allows self-archiving of both the pre-print (draft of a manuscript) and the post-print (the corrected and peer-reviewed version) and even the final version (layout as it will be published in the journal) both in personal repositories and in institutional and databases.