Anti-gliadin antibodies as a factor associated with lack of response to hepatitis B vaccination in adults

  • Miriam Ivonne Fernández Nieto Universidad Técnica de Ambato. Facultad de Ciencias de la Salud. Carrera de Enfermería. Ambato-Tungurahua. Ecuador
  • Nereida Josefina Valero Cedeño Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador http://orcid.org/0000-0003-3496-8848
  • Kathiuska Jamileth Hidalgo Ramirez Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador
  • Carlos Eduardo Toapanta Figueroa Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador
DOI: https://doi.org/10.56903/kasmera.5035706
Keywords: immunity, antibodies, hepatitis B, gliadin

Abstract

Hepatitis B is a disease that affects 350 million people in the world. There are factors such as age, sex, overweight, immunological diseases, diabetes mellitus, among others, that prevent the correct immune response to the hepatitis B vaccination. The objective of the research was to analyze the presence of antigliadin antibodies and the lack of response to vaccination against hepatitis B in adults. The descriptive-non-experimental design methodology, prospective, cross-sectional and explanatory, included 235 selected adults without distinction of sex or ethnicity with a history of vaccination against hepatitis B virus in whose serum samples antibodies against hepatitis B virus surface antigen were determined. Statistical analysis was performed with the Graph Pad Prism 8.0® software. antibodies against hepatitis B virus surface antigen were present in 76% of the population studied. 35.5% had elevated antigliadin antibodies associated with a hyporesponsiveness to the hepatitis B virus vaccine. Factors such as body mass index and family history of type 1 and 2 diabetes mellitus in the adults studied were significantly associated with the lack of immune response in non-responders

Author Biography

Nereida Josefina Valero Cedeño, Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador

Degree in Bioanalysis. Magister Scientiarum in Biology, Mention Basic Immunology. Doctor in Immunology. Postdoctorate in Immunology and Infectious Diseases. Teacher-Researcher hired. Clinical Laboratory Career. Faculty of Health Sciences. Southern State University of Manabi. Manabí-Ecuador, among the different positions held, are former Director of the Institute of Clinical Research “Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former head of the Virology Section. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former director of the Research Division of the Faculty of Medicine, Universidad del Zulia. Maracaibo Venezuela. Ex-coordinator of the Research Master in Biomedicine. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Ex-coordinator of the Master in Infectious Diseases of the University of Alcalá, Spain. Professional experience in the areas of immunology and virology. His research focuses on the diagnosis and epidemiology of emerging and reemerging viral infections such as Venezuelan equine encephalitis, dengue fever, yellow fever and respiratory syncytial virus among others. He has presented numerous communications to congresses and lectured at national and international scientific events. He has published more than 110 scientific papers in refereed journals, as well as reviews, chapters in books and monographs, both nationally and internationally. Member of the Editing Commission and expert evaluator in the area of immunology and virology of the Clinical Research Journals, Kasmera, REDIELUZ, Medical Journal of the Dr. Adolfo Pons Hospital and of the Ibero-American Journal of Applied Research. Member of the Venezuelan Society of Microbiology, Member of the American Society of Tropical Medicine and Hygiene (ASTMH) and Member of the Venezuelan Association for the Advancement of Science (AsoVAC).

E-mail: nere98@hotmail.com  valero.nereida@gmail.com

ORCID ID: https://orcid.org/0000-0003-3496-8848

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Published
2022-12-20
How to Cite
1.
Fernández Nieto MI, Valero Cedeño NJ, Hidalgo Ramirez KJ, Toapanta Figueroa CE. Anti-gliadin antibodies as a factor associated with lack of response to hepatitis B vaccination in adults. Kasmera [Internet]. 2022Dec.20 [cited 2024Nov.27];50:e5035706. Available from: https://mail.produccioncientificaluz.org/index.php/kasmera/article/view/35706
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Vol. 50 (2022)
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Original Articles

Copyright (c) 2022 Miriam Ivonne Fernández Nieto, Nereida Josefina Valero Cedeño, Kathiuska Jamileth Hidalgo Ramirez, Carlos Eduardo Toapanta Figueroa

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