Aminotransferases and lipid profile in Ecuadorian patients with active dengue virus infection

  • Teresa Isabel Veliz Castro Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador
  • Nereida Josefina Valero Cedeño South Manabi State University. Faculty of Health Sciences. Clinical Laboratory Career. http://orcid.org/0000-0003-3496-8848
  • Pionce Parrales Alexandra Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. Ecuador
  • Torres Portillo Mariana Clinician Surveillance Analyst at BlueDot INC-Toronto- Ontario, Canadá
DOI: https://doi.org/10.56903/kasmera.5036015
Keywords: dengue, lipoproteins, lipids, cholesterol, immunity, patients

Abstract

Dengue is the arbovirus with the highest incidence worldwide. Approximately 100 million cases of dengue with warning signs and between 250,000 and 500,000 cases of severe dengue are registered annually. In Ecuador, in the last four years, 83,472 cases of dengue have been registered. Previous studies show an increase in cases with liver dysfunction. The objective of this study was to analyze the association between serum levels of the aspartate aminotransferase enzyme and alanine aminotransferase and the lipid profile in patients with confirmed Dengue infection. 110 selected patients were studied without distinction of age, gender or origin, whose diagnosis was confirmed virologically and serologically. A virus seronegative control group was included. In the lipid profile, significant differences (p<0.003) were found in total cholesterol values ​​and in secondary infections; while the frequency of elevation of both aminotransferases was high in patients with dengue, however, quantitatively comparing serum values ​​did not show significant changes or association. The endemicity of dengue is confirmed, as well as the changes in the lipid profile, however, the need for population studies taking into account the genetics of the populations is evident

Author Biography

Nereida Josefina Valero Cedeño, South Manabi State University. Faculty of Health Sciences. Clinical Laboratory Career.

Degree in Bioanalysis. Magister Scientiarum in Biology, Mention Basic Immunology. Doctor in Immunology. Postdoctorate in Immunology and Infectious Diseases. Teacher-Researcher hired. Clinical Laboratory Career. Faculty of Health Sciences. Southern State University of Manabi. Manabí-Ecuador, among the different positions held, are former Director of the Institute of Clinical Research “Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former head of the Virology Section. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former director of the Research Division of the Faculty of Medicine, Universidad del Zulia. Maracaibo Venezuela. Ex-coordinator of the Research Master in Biomedicine. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Ex-coordinator of the Master in Infectious Diseases of the University of Alcalá, Spain. Professional experience in the areas of immunology and virology. His research focuses on the diagnosis and epidemiology of emerging and reemerging viral infections such as Venezuelan equine encephalitis, dengue fever, yellow fever and respiratory syncytial virus among others. He has presented numerous communications to congresses and lectured at national and international scientific events. He has published more than 110 scientific papers in refereed journals, as well as reviews, chapters in books and monographs, both nationally and internationally. Member of the Editing Commission and expert evaluator in the area of immunology and virology of the Clinical Research Journals, Kasmera, REDIELUZ, Medical Journal of the Dr. Adolfo Pons Hospital and of the Ibero-American Journal of Applied Research. Member of the Venezuelan Society of Microbiology, Member of the American Society of Tropical Medicine and Hygiene (ASTMH) and Member of the Venezuelan Association for the Advancement of Science (AsoVAC).

E-mail: nere98@hotmail.com  valero.nereida@gmail.com

ORCID ID: https://orcid.org/0000-0003-3496-8848

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Published
2022-12-20
How to Cite
1.
Veliz Castro TI, Valero Cedeño NJ, Alexandra PP, Mariana TP. Aminotransferases and lipid profile in Ecuadorian patients with active dengue virus infection. Kasmera [Internet]. 2022Dec.20 [cited 2025Jan.9];50:e5036015. Available from: https://mail.produccioncientificaluz.org/index.php/kasmera/article/view/36015
Issue
Vol. 50 (2022)
Section
Original Articles

Copyright (c) 2022 Teresa Isabel Veliz Castro, Nereida Josefina Valero Cedeño, Pionce Parrales Alexandra, Torres Portillo Mariana

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