PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION

  • A Lugo de Yarbuh José Francisco Torrealba Parasitological Research Laboratory. Science Faculty. University of the Andes. Merida
  • C Colasante Electronic Microscopy Center. University of Los Andes, Mérida
Keywords: Chagas' disease, skeletal muscle, nerve fibers, motor activity

Abstract

Clinical observations were made of mice in the acute stage of infection produced by three Trypanosoma cruzi strains. Mice infected with Dm74 suffered complete paralysis of the rear limbs followed by death, while still in the acute stage of Chagas' disease. Hystological analysis of skeletal muscle showed intense inflammatory infiltrates of mononuclear and polymorphonuclear leukocytes, fibroblasts, free red blood cells and IgG deposits in the interstilium of Gastrocnemius (G). Local miofibrillic disintegration and changes in microvessels, nerve fibers and the neuromuscular junction of G were also observed. These results indicate that the acute infection with T. cruzi may cause progressive damage in parasite infected muscle fiber and lead to loss of mobility.

Published
2000-03-06
How to Cite
1.
Lugo de Yarbuh A, Colasante C. PATHOLOGICAL ASPECTS OF SKELETAL MUSCLE IN EXPERIMENTAL Trypanosoma cruzi INFECTION. Kasmera [Internet]. 2000Mar.6 [cited 2024Nov.22];28(3). Available from: https://mail.produccioncientificaluz.org/index.php/kasmera/article/view/4672
Issue
Vol. 28 No. 3 (2000)
Section
Original Articles

Copyright (c) 2000 A Lugo de Yarbuh, C Colasante

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