Pancreatic enzymes in patients with suspected acute pancreatitis in Ecuador
Pancreatic enzymes in patients with suspected acute pancreatitis in Ecuador
Keywords:
Acute Pancreatitis, Amylase Serum, Lipase Serum, Ecuador
Abstract
To diagnose acute pancreatitis (AP) it is essen-tial to determine pancreatitis enzymes. The objec-tive of this study is to analyze the characteristics of patients with suspected AP in whom Amylase and serum Lipase were determined, attended in a General Hospital of Ecuador. This research is des-criptive, retrospective and transversal. The clinical histories of patients with suspected AP during the year 2016 were reviewed. 200 histories were found, but 158 (79%) resulted PA. The average age was 51.4±13.01 years, predominantly female (58.23%), 50% were over 45 years old, 13.92% (22 cases) corresponded to severe PA and the etiology the most common was biliary (56.33%). In all patients the serum amylase serum concentration was three times higher than the normal level (up to 220 U/l), while 27.22% showed values higher than 500 U/l for the lipase (Normal value up to 60 U/). No pa-tient died. The characteristics of our patients were those expected in hospitalized patients, it is impor-tant to highlight the absence of deceased patients even though they are data from a small sample. It is advisable to detect and treat this pathology in a timely manner, in order to avoid complications such as pancreatic necrosis, infections and multiple or-gan failure.
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References
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Arvanitakis M., Delhaye M., De Maertelaere V., Bali M., Winant C., Coppens E., Jeanmart J., Zalcman M., Van GANSBEKE D., Deviere J., Matos C. (2004). Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology. 126 (3): 715-23.
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Balthazar E. (2002). Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology. 223: 603-13.
Bradley E. (1993). A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 throw 13. Arch Surg. 128: 586-90.
Cáceres F., Cáceres R. (2018). Pancreatitis aguda. Una visión global. En: López
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Corfield A., Cooper M., Williamson R. (1985). Acute pancreatitis a lethal disease of increasing incidence. Gut. 26: 724-9.
De Campos T., Parreira J., Utiyama E., Rasslan S. (2008) Pesquisa nacional sobre condutas na pancreatite aguda. Rev Col Bras Cir. 35 (5): 304-10.
Di Magno E., Chari S. (2002). Acute Pancreatitis. In: Feldman (ed). Sleisenger & Fordtran’s Gastrointestinal and Liver Disease, 7th Ed. Philadelphia: Saunders p. 913-41.
Dick J., Gardner T., Merrens E. (2016). Acute pancreatitis: New developments and strategies for the hospitalist. J Hosp Med. 11: 724-72.
Dominguez J. (2010). Diagnosis of chronic pancreatitis: Functional testing. Best Pract Res Clin Gastroenterology. 2 (4): 233-41.
Duffy Verdura B., Mijares García J., Ortega Cudillo L., Pérez Trigos H., Cárdenas Lailson L. (2003). Comparación de dos sistemas pronósticos de parámetros múltiples (APACHE II y Ranson) en pancreatitis aguda. Ciruj Gen. 25 (2): 112-118.
Dumnicka P., Maduzia D., Ceranowicz P., Olsza necki R., Drozdz R., Kusnierz.Cabala B. (2017). The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: Clinical implications. Int J Mol Sci 18 (2): 354.
Eland I., Sturkenboom M., Wilson J., Stricker B. (2002). Incidence of acute pancreatitis (correspondence). Scand J Gastroenterol. 37: 124.
Forsmark C., Vege S. (2016). Acute pancreatitis. N Engl J Med. 375: 1972-1981.
Frossard J., Steer M., Pastor C. (2008). Acute pancreatitis. Lancet. 371: 143-52.
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González González J., Castañeda Sepúlveda R., Martínez Vázquez M., García Compean D., Flores Rendón A., Maldonado Garza H., Bosques Padilla F., Garza Galindo A. (2012). Características clínicas de la pancreatitis aguda en México. Rev Gastroenterol Mex 77 (4):167- 173.
Gutiérrez I., Domínguez A., Acevedo J. (2003). Mecanismos fisiopatogénicos de la pancreatitis aguda. Cir Gen. 25: 95-102.
Habtezion A. (2015). Inflammation in acute and chronic pancreatitis. Curr Opin Gastroenterol 31: 1-12.
Hanck C., Whitcomb D. (2004). Alcoholic pancreatitis. Gastroenterol Clin North Am. 33: 751-65.
Heinrich S., Schafer M., Rousson V., Clavien P. (2006). Evidence based treatment of acute pancreatitis: a look at established paradigms. Ann Surg. 243: 154-68.
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Junquera R., Pereyra I. (2010). Pancreatitis aguda. Archivos de salud pública. Septiembre-Diciembre. 1: 24-30.
Kalra M., Maher M., Sahani D., Digmurthy S., Saini S. (2002). Current status of imaging in pancreatic diseases. Comput Assist Tomogr. 26: 661-75.
Kingsnorth A., O’Reilly D. (2006). Acute pancreatitis. 332: 1072-6.
Lankisch P., Schirren C., Kunze E. (1991). Undetected fatal acute pancreatitis: Why is the disease so frequently overlooked?. Am J Gastroenterol. 86: 322.
Lowenfels A., Sullivan T., Fiorianti J., Maisonneuve P. (2005). The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep. 7: 90-5.
Membrillo Romero A., González Lanzagorta R., Rascón Martínez D. (2017). Evaluación de los niveles de amilasa y lipasa posterior a la realización de biopsia. Cirugía y Cirujanos. 85 (5): 387-392.
Ministerio de Salud (MINSA). (2009). Perfil epidemiológico de pacientes en consulta externa y hospitalización. MINSA. Lima-Perú.
Ocampo C., Kohan G., Leiro F., Basso S., Gutiérrez S., Perna L., Serafini V., Lada P., Lancelot T, García H., Tolino M., Stork G., Zandalazini H., Buonomo L., Mercade J., Ferreres A., Troubul F., Latif J., Klappenbach R., Capitanich P., Rainori P., Sisco P., Zartarian D., Alvarez S., Fraile A., (2015). Diagnóstico y tratamiento de la pancreatitis aguda en la Argentina. Resultados de un estudio prospectivo en 23 centros. Acta Gastroenterol Latinoam 45 (4): 295-302.
Pacheco R., Nishioka S., de Oliveira L. (2003). Validity of serum amylase and lipase in the differential diagnosis between acute/acutized chronic pancreatitis and other causes of acute abdominal pain. Arq Gastroenterol.40: 233-238.
Pamuklar E., Semelka R. (2005). MR imaging of the pancreas. Magn Reson Imaging Clin North Am. 13:313-30.
Parniczky A., Kui B., Szentesi A., Balazs A, Szucs A., Mosztbacher D., Szimmer J., Hungarian Pancreatic Study Group. (2016). Prospective, multi centre, nationwide clinical data from 600 cases of acute pancreatitis. PLoS One. 11: 1-19.
Pellegrini D., Pankl S., Finn B., Bruetman J., Zubiaurre I., Young P. (2009). Pancreatitis Aguda. Análisis de 97 pacientes. Medicina (Buenos Aires) 2009. 69: 239-245.
Portelli M., Jones C. (2017). Severe acute pancreatitis: Pathogenesis, diagnosis and surgical management. Hepatobiliary Pancreat. Dis Int. 16: 155- 159.
Quinlan J. (2014). Acute pancreatitis. Medico Am Fam. 90: 632-639.
Singh V., Wu B., Bollen TL., Repas K., Maurer R., Johannes RS., Mortele KJ., Conwell DL., Banks PA. (2009). A prospective evaluation of the bedside index for severity in acute pancreatitis score in assessing mortality and intermediate markers of severity in acute pancreatitis. Am J Gastroenterol. 104 (4): 966-71.
Skipworth J., Pereira S. (2008). Acute pancreatitis. Curr Opin Crit Care. 14: 172-8.
Swaroop V., Chari S., Clain J. (2004). Severe acute pancreatitis. JAMA 291 (23): 2865-8.
Tenner S., Baillie J., DeWitt J., Vege S. (2013). American College of Gastroenterology American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 108 (9):1400-1415.
Toouli J., Brooke Smith M., Bassi C., Carr Locked D., Telford J., Freeny P., Imrie C., Tandon R., Working party of the program committee of the Bangkok world congress of gastroenterology. (2002). Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol. Febrero; 17 Suppl: S15-39.
Whitcomb D. (2006). Acute pancreatitis. N Engl J Med. 354: 2142-50.
Wilson C., Imrie C. (1986). Amylase and gut infarction. Br J Surg. 73: 219-221
Working Group IAP/APA. (2013). Acute Pancreatitis Guidelinesa IAP/APA evidence based guidelines for the management of acute pancreatitis. Pancreatol. 13: 1-15.
Working Party of the British Society of Gastroenterology (WPBSG). (2005). UK guidelines for the management of acute pancreatitis. Gut 54 (Suppl. 3), iii1-iii9.
Yousaf M., McCallion K., Diamond T. (2003). Management of severe acute pancreatitis. Br J Surg 90: 407-20.
American Gastroenterological Association (AGA) Institute. (2007). AGA Institute Technical Review on Acute Pancreatitis. Gastroenterology. 132: 2022-44.
Arvanitakis M., Delhaye M., De Maertelaere V., Bali M., Winant C., Coppens E., Jeanmart J., Zalcman M., Van GANSBEKE D., Deviere J., Matos C. (2004). Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology. 126 (3): 715-23.
Balthazar E. (1989). CT diagnosis and staging of acute pancreatitis. Radiol Clin North Am. 27: 19-37.
Balthazar E. (2002). Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology. 223: 603-13.
Bradley E. (1993). A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 throw 13. Arch Surg. 128: 586-90.
Cáceres F., Cáceres R. (2018). Pancreatitis aguda. Una visión global. En: López
Fernández F. Organización administrativa y gestión terapéutica. Capítulo 9. Asociación Cultural y Científica Iberoamericana. Madrid España.
Corfield A., Cooper M., Williamson R. (1985). Acute pancreatitis a lethal disease of increasing incidence. Gut. 26: 724-9.
De Campos T., Parreira J., Utiyama E., Rasslan S. (2008) Pesquisa nacional sobre condutas na pancreatite aguda. Rev Col Bras Cir. 35 (5): 304-10.
Di Magno E., Chari S. (2002). Acute Pancreatitis. In: Feldman (ed). Sleisenger & Fordtran’s Gastrointestinal and Liver Disease, 7th Ed. Philadelphia: Saunders p. 913-41.
Dick J., Gardner T., Merrens E. (2016). Acute pancreatitis: New developments and strategies for the hospitalist. J Hosp Med. 11: 724-72.
Dominguez J. (2010). Diagnosis of chronic pancreatitis: Functional testing. Best Pract Res Clin Gastroenterology. 2 (4): 233-41.
Duffy Verdura B., Mijares García J., Ortega Cudillo L., Pérez Trigos H., Cárdenas Lailson L. (2003). Comparación de dos sistemas pronósticos de parámetros múltiples (APACHE II y Ranson) en pancreatitis aguda. Ciruj Gen. 25 (2): 112-118.
Dumnicka P., Maduzia D., Ceranowicz P., Olsza necki R., Drozdz R., Kusnierz.Cabala B. (2017). The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: Clinical implications. Int J Mol Sci 18 (2): 354.
Eland I., Sturkenboom M., Wilson J., Stricker B. (2002). Incidence of acute pancreatitis (correspondence). Scand J Gastroenterol. 37: 124.
Forsmark C., Vege S. (2016). Acute pancreatitis. N Engl J Med. 375: 1972-1981.
Frossard J., Steer M., Pastor C. (2008). Acute pancreatitis. Lancet. 371: 143-52.
Go V., Everhart J. (1994). Pancreatitis. In: Everhart JE (ed): Digestive Diseases in the United States: Epidemiology and Impact. Ed Washington DC: Diane Publishing, p. 693-712.
González González J., Castañeda Sepúlveda R., Martínez Vázquez M., García Compean D., Flores Rendón A., Maldonado Garza H., Bosques Padilla F., Garza Galindo A. (2012). Características clínicas de la pancreatitis aguda en México. Rev Gastroenterol Mex 77 (4):167- 173.
Gutiérrez I., Domínguez A., Acevedo J. (2003). Mecanismos fisiopatogénicos de la pancreatitis aguda. Cir Gen. 25: 95-102.
Habtezion A. (2015). Inflammation in acute and chronic pancreatitis. Curr Opin Gastroenterol 31: 1-12.
Hanck C., Whitcomb D. (2004). Alcoholic pancreatitis. Gastroenterol Clin North Am. 33: 751-65.
Heinrich S., Schafer M., Rousson V., Clavien P. (2006). Evidence based treatment of acute pancreatitis: a look at established paradigms. Ann Surg. 243: 154-68.
Instituto Nacional de estadísticas y Censo (INEC). (2011). Anuario de estadísticas hospitalarias: Egresos y Camas. Disponible en: https://www. ecuadorencifras.gob.ec /anuarios estadísticos.
Instituto Nacional de estadísticas y Censo (INEC). (2013). Anuario de estadísticas hospitalarias: Egresos y Camas. Disponible en: https://www. ecuadorencifras.gob.ec /anuariosestadisticos2/
Junquera R., Pereyra I. (2010). Pancreatitis aguda. Archivos de salud pública. Septiembre-Diciembre. 1: 24-30.
Kalra M., Maher M., Sahani D., Digmurthy S., Saini S. (2002). Current status of imaging in pancreatic diseases. Comput Assist Tomogr. 26: 661-75.
Kingsnorth A., O’Reilly D. (2006). Acute pancreatitis. 332: 1072-6.
Lankisch P., Schirren C., Kunze E. (1991). Undetected fatal acute pancreatitis: Why is the disease so frequently overlooked?. Am J Gastroenterol. 86: 322.
Lowenfels A., Sullivan T., Fiorianti J., Maisonneuve P. (2005). The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep. 7: 90-5.
Membrillo Romero A., González Lanzagorta R., Rascón Martínez D. (2017). Evaluación de los niveles de amilasa y lipasa posterior a la realización de biopsia. Cirugía y Cirujanos. 85 (5): 387-392.
Ministerio de Salud (MINSA). (2009). Perfil epidemiológico de pacientes en consulta externa y hospitalización. MINSA. Lima-Perú.
Ocampo C., Kohan G., Leiro F., Basso S., Gutiérrez S., Perna L., Serafini V., Lada P., Lancelot T, García H., Tolino M., Stork G., Zandalazini H., Buonomo L., Mercade J., Ferreres A., Troubul F., Latif J., Klappenbach R., Capitanich P., Rainori P., Sisco P., Zartarian D., Alvarez S., Fraile A., (2015). Diagnóstico y tratamiento de la pancreatitis aguda en la Argentina. Resultados de un estudio prospectivo en 23 centros. Acta Gastroenterol Latinoam 45 (4): 295-302.
Pacheco R., Nishioka S., de Oliveira L. (2003). Validity of serum amylase and lipase in the differential diagnosis between acute/acutized chronic pancreatitis and other causes of acute abdominal pain. Arq Gastroenterol.40: 233-238.
Pamuklar E., Semelka R. (2005). MR imaging of the pancreas. Magn Reson Imaging Clin North Am. 13:313-30.
Parniczky A., Kui B., Szentesi A., Balazs A, Szucs A., Mosztbacher D., Szimmer J., Hungarian Pancreatic Study Group. (2016). Prospective, multi centre, nationwide clinical data from 600 cases of acute pancreatitis. PLoS One. 11: 1-19.
Pellegrini D., Pankl S., Finn B., Bruetman J., Zubiaurre I., Young P. (2009). Pancreatitis Aguda. Análisis de 97 pacientes. Medicina (Buenos Aires) 2009. 69: 239-245.
Portelli M., Jones C. (2017). Severe acute pancreatitis: Pathogenesis, diagnosis and surgical management. Hepatobiliary Pancreat. Dis Int. 16: 155- 159.
Quinlan J. (2014). Acute pancreatitis. Medico Am Fam. 90: 632-639.
Singh V., Wu B., Bollen TL., Repas K., Maurer R., Johannes RS., Mortele KJ., Conwell DL., Banks PA. (2009). A prospective evaluation of the bedside index for severity in acute pancreatitis score in assessing mortality and intermediate markers of severity in acute pancreatitis. Am J Gastroenterol. 104 (4): 966-71.
Skipworth J., Pereira S. (2008). Acute pancreatitis. Curr Opin Crit Care. 14: 172-8.
Swaroop V., Chari S., Clain J. (2004). Severe acute pancreatitis. JAMA 291 (23): 2865-8.
Tenner S., Baillie J., DeWitt J., Vege S. (2013). American College of Gastroenterology American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 108 (9):1400-1415.
Toouli J., Brooke Smith M., Bassi C., Carr Locked D., Telford J., Freeny P., Imrie C., Tandon R., Working party of the program committee of the Bangkok world congress of gastroenterology. (2002). Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol. Febrero; 17 Suppl: S15-39.
Whitcomb D. (2006). Acute pancreatitis. N Engl J Med. 354: 2142-50.
Wilson C., Imrie C. (1986). Amylase and gut infarction. Br J Surg. 73: 219-221
Working Group IAP/APA. (2013). Acute Pancreatitis Guidelinesa IAP/APA evidence based guidelines for the management of acute pancreatitis. Pancreatol. 13: 1-15.
Working Party of the British Society of Gastroenterology (WPBSG). (2005). UK guidelines for the management of acute pancreatitis. Gut 54 (Suppl. 3), iii1-iii9.
Yousaf M., McCallion K., Diamond T. (2003). Management of severe acute pancreatitis. Br J Surg 90: 407-20.
Published
2021-03-13
How to Cite
Salazar Carranza, L. A., Castro Posligua, A. Águeda, & Robledo Galeas, S. S. (2021). Pancreatic enzymes in patients with suspected acute pancreatitis in Ecuador: Pancreatic enzymes in patients with suspected acute pancreatitis in Ecuador. REDIELUZ, 10(2), 50-55. Retrieved from https://mail.produccioncientificaluz.org/index.php/redieluz/article/view/35517
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Health Sciences
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