Clinical value of combined detection of thrombus precursor protein and P-selectin in the diagnosis of acute coronary syndrome.
Valor clínico de la detección combinada de proteína precursora de trombo y selectina P en el diagnóstico del síndrome coronario agudo.
Abstract
Acute coronary syndrome (ACS), including acute myocardial infarction (AMI) and unstable angina (UA), is the most threatening and lethal form of coronary heart disease. ACS has an abrupt onset and rapid development, which may lead to fatal conditions at any time. Thus, it is never too early to detect and diagnose patients with ACS. The objective of this work was to explore the significance of the combined detection of plasma thrombus precursor protein (TpP) and serum P-selectin (Ps), in the detection and diagnosis of patients with early ACS. A total of 126 subjects were included in the study, 64 ACS patients, 30 individuals with stable angina (SA) and 32 healthy persons who were selected as the control groups. There were no differences in gender, age, ethnicity, or blood glucolipid levels among the groups. Enzyme linked immunosorbent assay (Elisa) was used to quantitatively determine the plasma levels of TpP and Ps. The levels of the two biomarkers in the case group were significantly higher than those in the control groups. Among the ACS patients, the levels of TpP and Ps were higher in AMI patients than in the UA patients. In addition, there was no significant differences in the levels of Ps between SA patients and healthy persons. In conclusion, plasma TpP and serum Ps are remarkably increased in patients with ACS. Therefore, TpP and Ps may serve as ACS indicators, and their measurement may provide a support for an early clinical identification of ACS.
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References
Emergency Physician Branch of Chinese Medical Doctor Association. 2015 China Emergency Acute Coronary Syndrome Clinical Practice Guidelines (2)—Diagnosis. Chin Emerg Med 2016; 36(1): 9-11.
Giustino G, Baber U, Stefanini GG, Aquino M, Stone GW, Sartori S, Steg PG, Wijns W, Smits PC, Jeger RV, Leon MB, Windecker S, Serruys PW, Morice MC, Camenzind E, Weisz G, Kandzari D, Dangas GD, Mastoris I, Von Birgelen C, Galatius S, Kimura T, Mikhail G, Itchhaporia D, Mehta L, Ortega R, Kim HS, Valgimigli M, Kastrati A, Chieffo A, Mehran R. Impact of clinical presentation (Stable Angina Pectoris vs Unstable Angina Pectoris or Non-ST-Elevation Myocardial Infarction vs ST-Elevation Myocardial Infarction) on long-term outcomes in women undergoing percutaneous coronary intervention with drug-eluting stents. Am J Cardiol 2015; 116(6):845-852.
Song Z, Wang XP. The significance of thrombus precursor protein in the diagnosis of thrombotic diseases. Tianjin Med J 2007,35(4):312-314.
Semenov AV, Kogan-Ponomarev MI, Ruda MIa, Komarov AL, Panchenko EP, Chazova IE, Mazurov AV. Soluble P-selectin a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension. Ter Arkh 2000; 72(4): 15-20.
Li-Sha G, Peng C, Yue-Chun L. Recurrent acute coronary syndrome and restenosis after percutaneous coronary intervention in a patient with idiopathic thrombocytopenic purpura: a case report and literature review. BMC Cardiovasc Disord 2015; 15:101.
Song YP, Wang WJ, Xu ZC, Zhang YH. The prognostic value of d-dimer, high-sensitivity C-reactive protein and brain natriuretic peptide in acute coronary syndrome. Chin Gen Pract 2007,10(10):801-803.
Chu J, He XD, Ye SL, Zhai ZM. Detection of thrombus precursor protein and creatine kinase in patients with acute myocardial infarction and unstable angina. Chin J Arterios 2002; 10: 165-166.
Kabbani SS, Watkins MW, Holoch PA, Terrien EF, Sobel BE, Schneider DJ. Platelet reactivity in coronary ostial blood: a reflection of the thrombotic state accompanying plaque rupture and of the adequacy of antithrombotic therapy. J Thromb Thrombolysis 2001; 12: 171- 176.
Jiang JC, Rong QJ. The significance of P-selectin, C-reactive protein and troponin I on the short-term prognosis of patients with acute coronary syndrome. Mod Pract Med 2011; 2: 182-183.
Chen ZQ, Hong L, Wang H, Yin QL, Lai HL, Lu LX, Ge YZ. Changes and clinical significance of plasma P-selectin, glycoprotein/Ⅲa, fibrinogen and high-sensitivity C-reactive protein in elderly patients with acute coronary syndrome. Chin Gerontol Mag 2010,30(22):3269-3270.
Atalar E, Aytemir K, Haznedaroğlu I, Ozer N, Ovünç K, Aksöyek S, Kes S, Kirazli S, Ozmen F. Increased plasma levels of soluble selectins in patients with unstable angina. Int J Cardiol 2001; 78: 69-73.
Kayikçioglu M, Can L, Mete-Erdem N, Kültürsay H, Payzin S, Kokuludag A, Türkoglu C. Soluble p-selectin and the success of thrombolysis in acute myocardial infarction. Int J Cardiol 2001; 79: 223-229.
Shebuski RJ, Kilgore KS. Role of inflammatory mediators in thrombogenesis. J Pharmacol Exp Ther 2002; 300(3):729-735.
Carter AM, Anagnostopoulou K, Mansfield MW, Grant PJ. Soluble P-select in levels, P-selectin polymorphisms and cardio-vasculardisease. J Thromb Haemost 2003, 1(8):1718-1723.
Zhao GQ, Guo ZF. Correlation analysis of fibrinogen, thrombus precursor protein and severity of coronary artery disease in patients with coronary heart disease. J pract clin med 2018; 22 (22): 1-4.
